Register NOW

Antibacterial Peptide Could Aid in Treating Soldiers' Burn Wound Infections

ScienceDaily (Sep. 2, 2010) — An antibacterial peptide developed by Laszlo Otvos, a research professor of biology in Temple's College of Science and Technology, looks to be a highly-effective therapy against infections in burn or blast wounds suffered by soldiers.

Otvos and his collaborators found that when given intramuscularly the peptide A3-APO was more effective than current antimicrobial chemotherapy measures in treating multidrug-resistant Acinetobacter baumannii, the most common systemic infection found in soldiers who suffer burn or blast wounds. The peptide is also highly efficacious in models of multi-drug resistant systemic Escherichia coli infections.

Their findings are being published in the Journal of Antimicrobial Chemotherapy.

Otvos said that 40 percent of gowns and gloves in military hospitals are infected with Acinetobacter baumannii, and half of the soldiers returning from Iraq and Afghanistan with burn wounds will become infected.

Currently, these infections are treated with an antibiotic, either imipenem or colistin. However, both of these rapidly lose efficacy due to high rates of antimicrobial resistance. In addition, colistin is a strongly toxic drug and worldwide research is focusing on its replacement options.
For their study, the researchers used a strain of Acinetobacter baumannii isolated from an injured Canadian soldier returning from Afghanistan for testing in the lab. They found that A3-APO, when given intramuscularly, was less toxic and more effective in reducing bacterial counts in the blood and the injury site than imipenem or colistin. The peptide also protected open wounds from environmental bacterial infection.

"This is the first peptide ever that is more efficacious in an animal model than anything else that is available," said Otvos, who hopes the peptide can be tested in clinical trials in the near future.
 
MilitaryConnection.com thanks you for your patronage.  This website is a portal of all things military and is quickly becoming the "go to" website of the military community.  We are constantly adding resources, content and features that benefit our audience on a variety of levels.  All of our information and resources are free to users and there is something for everyone.  MilitaryConnection.com salutes and commends military medical professionals for their dedication, commitment and outstanding achievement in the military realm.  The medical personnel responsible for maintaining our military health system from physicians and nurses to our allied health professionals is held in high regard at MilitaryConnection.com.  They are using cutting edge medicine and saving lives daily.  They also improve and maintain the quality of the lives they save.  These military healthcare professionals are outstanding and make incredible additions to civilian healthcare organizations when they transition from the military.  MilitaryConnection.com offers a multitude of resources for healthcare professionals.  When the next tour is back home, it's on MilitaryConnection.com.